2020Xu H, Zhong L, Deng J, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci 2020; 12: 8.
2020Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506.
2020Coronavirus: Cytokine storm syndrome treatments for Covid-19 patients may cut death rates - Vox. https://www.vox.com/2020/3/12/21176783/coronavirus-covid-19-deaths-china-treatment- cytokine-storm-syndrome (accessed March 17, 2020).
2020Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ. COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 2020; 0. DOI:10.1016/S0140-6736(20)30628-0.
2020Thevarajan I, Nguyen THO, Koutsakos M, et al. Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nat Med 2020; : 1-3.
2020Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor Article SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell 2020; 181: 1-10.
2020Batlle D, Wysocki J, Satchell K. Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy? Clin Sci 2020; 134: 543-5.
2020Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir 2020. DOI:10.1016/S2213-2600(20)30116-8.
2020Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angi. https://www.escardio.org/Councils/Council-on-Hypertension-(CHT)/News/position-statement-of- the-esc-council-on-hypertension-on-ace-inhibitors-and-ang (accessed March 16, 2020).
2020Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: 2 An analysis based on decade-long structural studies of SARS 3 4 Downloaded from. 2020. DOI:10.1128/JVI.00127-20.
2020Chen, Xiaohua, et al. Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients. medRxiv, 2020.
2018Santos RAS, Sampaio WO, Alzamora AC, et al. The ACE2/Angiotensin-(1-7)/Mas axis of the renin- angiotensin system: Focus on Angiotensin-(1-7). Physiol. Rev. 2018; 98: 505-53.
2018Sodhi CP, Wohlford-Lenane C, Yamaguchi Y, et al. Attenuation of pulmonary ACE2 activity impairs inactivation of des-arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration. Am J Physiol - Lung Cell Mol Physiol 2018; 314: L17-31.
2018Shim KY, Eom YW, Kim MY, Kang SH, Baik SK. Role of the renin-angiotensin system in hepatic fibrosis and portal hypertension. Korean J. Intern. Med. 2018; 33: 453-61.
2018Oakes JM, Fuchs RM, Gardner JD, Lazartigues E, Yue X. Nicotine and the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 2018; 315: R895-906.
2018Menachery VD, Schäfer A, Burnum-Johnson KE, et al. MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape. Proc Natl Acad Sci U S A 2018; 115: E1012-21.
2017Li XC, Zhang J, Zhuo JL. The vasoprotective axes of the renin-angiotensin system: physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases Graphical abstract HHS Public Access. DOI:10.1016/j.phrs.2017.06.005.
2017Rodrigues Prestes TR, Rocha NP, Miranda AS, Teixeira AL, Simoes-e-Silva AC. The Anti-Inflammatory Potential of ACE2/Angiotensin-(1-7)/Mas Receptor Axis: Evidence from Basic and Clinical Research. Curr Drug Targets 2017; 18. DOI:10.2174/1389450117666160727142401.
2017Lieben L. Alport syndrome: ACE2 administration slows kidney damage. 2017. DOI:10.1016/j.
2017Ghadhanfar E, Alsalem A, Al-Kandari S, Naser J, Babiker F, Al-Bader M. The role of ACE2, angiotensin- (1-7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reprod Biol Endocrinol 2017; 15. DOI:10.1186/s12958-017-0316-8.
2016Kim ES, Choe PG, Park WB, et al. Clinical progression and cytokine profiles of middle east respiratory syndrome coronavirus infection. J Korean Med Sci 2016; 31: 1717-25.
2016Ahmadian E, Pennefather PS, Eftekhari A, Heidari R, Eghbal MA. Role of renin-angiotensin system in liver diseases: an outline on the potential therapeutic points of intervention. Expert Rev. Gastroenterol. Hepatol. 2016; 10: 1279-88.
2015Bennion DM, Haltigan E, Regenhardt RW, Steckelings UM, Sumners C. Neuroprotective Mechanisms of the ACE2-Angiotensin-(1-7)-Mas Axis in Stroke. Curr. Hypertens. Rep. 2015; 17. DOI:10.1007/s11906-014-0512-2.
2015Qiao W, Wang C, Chen B, et al. Ibuprofen Attenuates Cardiac Fibrosis in Streptozotocin-Induced Diabetic Rats. Cardiology 2015; 131: 97-106.
2014Patel VB, Clarke N, Wang Z, et al. Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS. J Mol Cell Cardiol 2014; 66: 167-76.
2014Deshotels MR, Xia H, Sriramula S, Lazartigues E, Filipeanu CM. Angiotensin II mediates angiotensin converting enzyme type 2 internalization and degradation through an Angiotensin II type I receptor- dependent mechanism. Hypertension 2014; 64: 1368-75.
2013Perlot T, Penninger JM. ACE2 - From the renin-angiotensin system to gut microbiota and malnutrition. Microbes Infect. 2013; 15: 866-73.
2012Zhou P, Yang X-L, Wang X-G, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. 270 | Nat | 2012; 579. DOI:10.1038/s41586-020-2012-7.
2012Tikellis C, Thomas MC. Angiotensin-Converting Enzyme 2 (ACE2) Is a Key Modulator of the Renin Angiotensin System in Health and Disease. Int J Pept 2012; 2012. DOI:10.1155/2012/256294.
2012Moh Zaki A, Van Boheemen S, Bestebroer TM, Osterhaus ADME, Fouchier RAM. Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia. NEJM.org N Engl J Med 2012; 367: 1814- 34.
2012Kawase M, Shirato K, Van Der Hoek L, Taguchi F, Matsuyama S. Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Severe Acute Respiratory Syndrome Coronavirus Entry. 2012; 86: 6537-45.
2010Batlle D, Soler MJ, Ye M. ACE2 and diabetes: ACE of ACEs? Diabetes. 2010; 59: 2994-6.
2010Wysocki J, Ye M, Rodriguez E, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: Prevention of angiotensin II-dependent hypertension. Hypertension 2010; 55: 90-8.
2010Matsuyama S, Nagata N, Shirato K, Kawase M, Takeda M, Taguchi F. Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2. J Virol 2010; 84: 12658-64.
2010Komukai K, Mochizuki S, Yoshimura M. Gender and the renin-angiotensin-aldosterone system. Fundam Clin Pharmacol 2010; 24: 687-98.
2008Koka V, Huang XR, Chung ACK, et al. Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway. Am J Pathol 2008; 172: 1174-83.
2008Koka V, Huang XR, Chung ACK, Wang W, Truong LD, Lan HY. Angiotensin II Up-Regulates Angiotensin I-Converting Enzyme (ACE), but Down-Regulates ACE2 via the AT1-ERK/p38 MAP Kinase Pathway. Am J Pathol 2008; 172: 1174-83.
2007Keidar S, Kaplan M, Gamliel-Lazarovich A. ACE2 of the heart: From angiotensin I to angiotensin (1-7). Cardiovasc. Res. 2007; 73: 463-9.
2007Soler MJ, Wysocki J, Ye M, Lloveras J, Kanwar Y, Batlle D. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice. Kidney Int 2007; 72: 614-23.
2006Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: Implications for albuminuria in diabetes. J Am Soc Nephrol 2006; 17: 3067-75.
2006Ingelfinger JR. ACE2: a new target for prevention of diabetic nephropathy? J Am Soc Nephrol 2006; 17: 2957-9.
2005Huang KJ, Su IJ, Theron M, et al. An interferon-γ-related cytokine storm in SARS patients. J Med Virol 2005; 75: 185-94.
2005Paizis G, Tikellis C, Cooper ME, et al. Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut 2005; 54: 1790-6.
2005Imai Y, Kuba K, Rao S, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 2005; 436: 112-6.
2005Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation 2005; 111: 2605-10.
2005Sims AC, Baric RS, Yount B, Burkett SE, Collins PL, Pickles RJ. Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs. J Virol 2005; 79: 15511-24.
2005Osterholm MT. Preparing for the Next Pandemic. N Engl J Med 2005; 352: 1839-42.
2004Marshall RP, Gohlke P, Chambers RC, et al. Angiotensin II and the fibroproliferative response to acute lung injury. Am J Physiol - Lung Cell Mol Physiol 2004; 286. DOI:10.1152/ajplung.00313.2002.
2004Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203: 631-7.
2004Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of Angiotensin-Converting Enzyme 2 after Myocardial Infarction by Blockade of Angiotensin II Receptors. Hypertension 2004; 43: 970-6.
2004Zulli A, Hare DL, Buxton BF, Black MJ. High dietary methionine plus cholesterol exacerbates atherosclerosis formation in the left main coronary artery of rabbits. Atherosclerosis 2004; 176: 83- 9.
2004Lely AT, Hamming I, van Goor H, Navis GJ. Renal ACE2 expression in human kidney disease. J Pathol 2004; 204: 587-93.
2003Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science (80- ) 2003; 300: 1394-9.
2003Drosten C, Günther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003; 348: 1967-76.
2003Li W, Moore MJ, Vasllieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003; 426: 450-4.
2002Crackower MA, Sarao R, Oliveira-dos-Santos AJ, Da Costa J, Zhang L. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002; 417: 822-8.
2002Santos, R. A., et al. Evidence that angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor mas. In: Hypertension. 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA: LIPPINCOTT WILLIAMS & WILKINS, 2002. p. 387-387.
2000Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin- converting enzyme: Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem 2000; 275: 33238-43.
2000Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res 2000; 87. DOI:10.1161/01.res.87.5.e1.
2000Gerber A, Welte T, Ansorge S, Bühling F. Expression of cathepsins B and L in human lung epithelial cells is regulated by cytokines. In: Advances in Experimental Medicine and Biology. Springer, Boston, MA, 2000: 287-92.
1995Morrell NW, Morris KG, Stenmark KR. Role of angiotensin-converting enzyme and angiotensin II in development of hypoxic pulmonary hypertension. Am J Physiol - Hear Circ Physiol 1995; 269. DOI:10.1152/ajpheart.1995.269.4.h1186.
1956Skeggs LT, Kahn Jr, Shumway NP. The preparation and function of the hypertensin-converting enzyme. J Exp Med 1956; 103: 295-9.