LET'SBE
ready!

List of natural compounds acting against coronavirus life cycle phases

Anti-HCoV is a collection of 174 natural compounds that were revealed to have antiviral action in one or more phases of the human coronaviruses replication. This collection was organized by ML Chiusano and her collaborators (Monticolo F. & Palomba E., De Santis R., Assentato L., Triscino V., Langella MC) to support the current fight to the disease.

Compound name, their chemical Classification, their Source, their Phase of action, their Target and methods of identification (In silico or In vitro) and, in case, Cell lines are indicated.

If you find helpful this table please cite http://letsbe-ready.org/ and "anti-HCoV: a web resource to collect natural compounds against human coronaviruses" Monticolo F. & Palomba E., De Santis R., Assentato L., Triscino V., Langella MC, Lanzotti V, Chiusano ML (submitted 2020).

Type a keyword to search the table:

3β-acetoxy friedelaneTerpenesE. Neriifolia (leaves)---HCoV-229EMRC-5Chang, F. R., et, al. (2012). Nat Prod Commun
3β-friedelanolTerpenesE. Neriifolia (leaves)---HCoV-229EMRC-5Chang, F. R., et, al. (2012). Nat Prod Commun
AndrographolideTerpenesA. paniculata--In silico prediction--Li, X.,et al., (2020) Preprints
BerbamineAlkaloidsBerberidaceae---HCoV-NL63-Islam MT et al. (2020) Phytother Res
CiclosporinCiclosporinsB. nivea--In silico prediction--Li, X.,et al., (2020) Preprints
CorylifolPyrans/Benzopyrans/Chromans/FlavonoidsP. corylifolia-- HCoV-OC43MRC-5Islam MT et al. (2020) Phytother Res
EmetineAlkaloidsU. ipecacuanha-- SARS-CoV-Islam MT et al. (2020) Phytother Res
EpitaraxerolTerpenesE. Neriifolia (leaves)---HCoV-229EMRC-5Chang, F. R., et, al. (2012). Nat Prod Commun
Extract from leaves-A. mexicana--In silico prediction--Li, X.,et al., (2020) Preprints
FramycetinNeomycinS. fradiae--In silico prediction--Li, X.,et al., (2020) Preprints
FriedelinTerpenesE. Neriifolia (leaves)---HCoV-229EMRC-5Chang, F. R., et, al. (2012). Nat Prod Commun
Leaf extract-P. lingua (Leaf)---SARS-CoV (BJ001, BJ006)Vero E6Li, S. Y., et al., (2005) Antivir res
LeptodactyloneBenzopyransB. sessilicarpa ---SARS-CoVVero E6Yang, QY., et al., (2007) J Asian Nat Prod Res
MimosineAmino acidsLeucena glauca--In silico prediction--Li, X.,et al., (2020) Preprints
MimuloneFlavonoidsP. tomentosa---SARS‑CoV-Islam MT et al. (2020) Phytother Res
Procyanidin B1Tannins/ProanthocyanidinsCinnamomi cortex-- HCoV-OC43 - HCoV- NL63 - MERS-CoV-Islam MT et al. (2020) Phytother Res
ProlineAmino acids---In silico prediction--Li, X.,et al., (2020) Preprints
PseudoephedrineAlkaloidsEphedraceae--In silico prediction--Li, X.,et al., (2020) Preprints
Resveratrol PhenolsV. vinifera; P. cuspidatum; V. macrocarpon---Mouse infected with MERS-CoV -Lin S.C., et al., (2017) BMC Infect Dis
Root extract-L. aggregate (Root)---SARS-CoV (BJ001, BJ006)Vero E6Li, S. Y., et al., (2005) Antivir res
RutamarinPyrans/BenzopyransB. sessilicarpa ---SARS-CoVVero E6Yang, QY., et al., (2007) J Asian Nat Prod Res
Saikosaponins AGlycosides/SaponinsBupleurum spp---HCoV-229E-Islam MT et al. (2020) Phytother Res
Saikosaponins CGlycosides/SaponinsBupleurum spp---HCoV-229E-Islam MT et al. (2020) Phytother Res
Saikosaponins DGlycosides/SaponinsBupleurum spp---HCoV-229E-Islam MT et al. (2020) Phytother Res
TapinarofPhenolsPhotorhabdus--In silico prediction--Li, X.,et al., (2020) Preprints
Whole plant extract-A. annua (Whole plant)---SARS-CoV (BJ001, BJ006)Vero E6Li, S. Y., et al., (2005) Antivir res
(-)-Epigallocatechin gallatePyrans/Benzopyrans/Chromans/FlavonoidsC. sinensisAutoproteolytic activation PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
(1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl 2-nitrobenzoateTerpenesA. paniculataAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
(S)-(1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl-2-amino-3-phenylpropanoateTerpenesA. paniculataAutoproteolytic activation 3CLpro - PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
2,2-Di(3-indolyl)-3-indoloneIndolesI. indigoticaAutoproteolytic activation 3CLpro - PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
3′-(3-methylbut-2-enyl)- 3′,4,7-trihydroxyflavaneFlavonoidsB. papyriferaAutoproteolytic activation 3CLpro or PLpro-HCoVs - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
3′-O-methyldiplacolFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
3′-O-methyldiplaconeFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
3-Isotheaflavin-3-gallatePolyphenolsBlack teaAutoproteolytic activationPLpro SARS-CoV-Islam MT et al. (2020) Phytother Res
4′-O-methyldiplacolFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
4′-O-methyldiplaconeFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
4-hydroxyisolonchocarpinFlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-MERS-CoV, SARS-CoV-Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
4'-O-methylbavachalconePhenolsP. corylifoliaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
6-geranyl-4′,5,7-trihydroxy-3′,5′-dimethoxyflavanoneFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
7-MethoxycryptopleurineQuinolizinesT. indicaAutoproteolytic activation 3CLpro or PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
8β-hydroxyabieta-9(11),13-dien-12-oneTerpenesC. regelianusAutoproteolytic activation3CLpro SARS-CoV-Islam MT et al. (2020) Phytother Res
Amentoflavone Pyrans/Benzopyrans/Chromans/FlavonoidsT. nuciferaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
AndrograpaninTerpenesA. paniculataAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Apigenin Pyrans/Benzopyrans/Chromans/FlavonoidsT. nuciferaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Bavachinin Pyrans/Benzopyrans/Chromans/FlavonoidsP. corylifoliaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
BerchemolGlycosides/GlucosidesS. maculataAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Beta-sitosterol Phytosterols/SitosterolI. indigoticaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
BiorobinGlycosidesF. benjaminaAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Broussochalcone APyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Broussochalcone BPyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro or PLpro-HCoVs - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Broussoflavan AFlavonoidsB. papyriferaAutoproteolytic activation 3CLpro or PLpro-HCoVs - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Broussonol EPyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-SARS‑CoV - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
CerevisterolPhytosterolsV. diffusaAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Chrysin-7-O-β-glucuronideFlavonoidsS. baicalensisAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Cinnamtannin B1Tannins/ProanthocyanidinsCinnamomi cortexAutoproteolytic activation3CLpro SARS‑CoV-Islam MT et al. (2020) Phytother Res
Cinnamtannin B1 TanninsCinnamomi cortexAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Cleistocaltone ATerpenesC. operculatusAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
CoumaroyltyramineAminesF. cymosi rhizoma - Anemarrhenae rhizoma Autoproteolytic activation 3CLpro - PLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
CurcuminDiarylheptanoidsCurcuma longaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
DeacetylcentapicrinGlycosidesS. macrospermaAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Diarylheptanoids DiarylheptanoidsA. japonica Autoproteolytic activation PLpro---Park, JY., et al., (2012) Biol Pharm Bull
Dihomo-γ-linolenic acidAutacoidsLepidii semen descurainiae semenAutoproteolytic activation 3CLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
DiplaconePyrans/Benzopyrans/Chromans/FlavonoidsP. tomentosaAutoproteolytic activation PLpro-HCoVs-Islam MT et al. (2020) Phytother Res
FlavonoidsFlavonoidsP. tomentosaAutoproteolytic activation PLpro-SARS-CoV (ulbani strain)-Cho, J. K., et al. (2013) Bioorg Med Chem
HinokininLignansC. obtusaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Indigo IndolesI. indigoticaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Isobavachalcone KetonesP. corylifoliaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
IsodecortinolSterolsV. diffusaAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
KaempferolPyrans/Benzopyrans/Chromans/FlavonoidsE. breviscapus - Anemarrhenae rhizoma - A. japonicae herba - Asteris radix et rhizoma - Chrysanthemi flos - Epimrdii herba - Eriobotryae folium - E. helioscopiae herba - F. flos - Floium mori - F. fructus - Fortunes bossfern rhizome - Ginkgo semen - H. multijugum maxim. - H. herba - H. dulcis semen - I. flos - Lepidii semen descurainiae semen - L. japonicae flos - Mori follum - Radix bupleuri - T. cacumen - Cortex mori - G. glabraAutoproteolytic activation 3CLpro - PLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
Kazinol APyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-SARS‑CoV - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Kazinol BPyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-SARS‑CoV - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Kazinol FPyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-SARS‑CoV - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Kazinol JPyrans/Benzopyrans/Chromans/FlavonoidsB. papyriferaAutoproteolytic activation 3CLpro - PLpro-SARS‑CoV - MERS-CoV, SARS-CoV-Islam MT et al. (2020) Phytother Res - Park, J. Y., et al. (2017). J Enzym Inhib Med Ch
Kouitchenside IXanthenes/XanthonesS. kouitchensisAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
LycorineAlkaloidsL. radiata (Stem cortex)Autoproteolytic activation 3CLpro-SARS-CoV (BJ001, BJ006) - SARS‑CoVVero E6Li, S. Y., et al., (2005) Antivir res - Islam MT et al. (2020) Phytother Res
MagnololLignansM. officinalisAutoproteolytic activation PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
MoupinamideCinnamatesCoptidis rhizomaAutoproteolytic activation PLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
Neobavaisoflavone Pyrans/Benzopyrans/Chromans/FlavonoidsP. corylifoliaAutoproteolytic activation PLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Oleanolic acidTerpenesS. kouitchensisAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
OuabainGlycosides/StophanthinsA. schimperi - S. gratusAutoproteolytic activationPLpro SARS-CoV-Islam MT et al. (2020) Phytother Res
Phaitanthrin DQuinazolinesI. indigoticaAutoproteolytic activation PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
PiceatannolStilbenesV. viniferaAutoproteolytic activation PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Procyanidin A2 TerpenesCinnamomi cortexAutoproteolytic activation 3CLpro or PLpro-HCoVs-Islam MT et al. (2020) Phytother Res
QuercetinFlavonoidsA. japonicae herba - Asteris radix et rhizoma - Chrysanthemi flos - Coptidis rhizoma - Epimrdii herba - E. breviscapus - E. folium - E. helioscopiae herba - F. flos - Floium mori - F. fructus - Ginkgo semen - H. multijugum maxim. - H. herba - H. dulcis semen - I. flos - Lepidii semen descurainiae semen - L. japonicae flos - Mori follum - Peucedani radix - Bupleuri radix - F. cymosi rhizoma - T. cacumen - Cortex mori - G. glabra - T. nuciferaAutoproteolytic activation 3CLpro - PLproIn silico prediction--Zhang, D. H., (2020) J Integr Med - Li, X.,et al., (2020) Preprints - Islam MT et al. (2020) Phytother Res
Quercetin-3-β-galactoside FlavonoidsH. perforatumAutoproteolytic activation 3CLpro-SARS-CoV-Chen, L. et al., (2006). Bioorg Med Chem
Rosmarinic acidBenzoatesS. verticillata L.Autoproteolytic activation 3CLpro - PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Rosmariquinone PhenanthrenesS. miltiorrhizaAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
SavininLignansP. santalinusAutoproteolytic activation 3CLpro-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Stigmast-5-en-3-olPhytosterolsS. binchuanensisAutoproteolytic activation 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Tannic acidPolyphenolsC. sinensisAutoproteolytic activation 3CLpro-SARS-CoV-Chen, C. N., et al. (2005) Ecam
Tanshinone IIaTerpenesPeucedani radixAutoproteolytic activation 3CLpro - PLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
(1S,2R,4aS,5R,8aS)-1-Formamido-1,4a-dimethyl-6-methylene-5-((E)-2-(2-oxo-2,5-dihydrofuran-3-yl)ethenyl)decahydronaphthalen-2-yl 5-((R)-1,2-dithiolan-3-yl) pentanoateTerpenesA. paniculataAutoproteolytic activation - Genomic RNA replication3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
2-((1R,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl benzoateTerpenesA. paniculataAutoproteolytic activation - Genomic RNA replication3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
2-(3,4-Dihydroxyphenyl)-2-[[2-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran-3-yl]oxy]-3,4-dihydro-2H-1-benzopyran-3,4,5,7-tetrolTannins/ProanthocyanidinsV. viniferaAutoproteolytic activation - Genomic RNA replication PLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
2β-Hydroxy-3, 4-seco-friedelolactone-27-oic acidFriedelolactones V. diffusaAutoproteolytic activation - Genomic RNA replication3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
AndrographisideTerpenesA. paniculataAutoproteolytic activation - Genomic RNA replication3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
BaicalinPyrans/Benzopyrans/Chromans/FlavonoidsS. baicalensisAutoproteolytic activation - Genomic RNA replication PLpro - RdRpIn silico predictionIn vitro antiviral activity against 10 isolates of SARS-CoVfRhK-4Chen, F., et al. (2004), J Clin Virol - Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Betulinic acidTerpenesCortex mori - F. Fructus - H. multijugum maxim. - T. cacumen - Eriobotryae folium - G. glabra - Peucedani radix Autoproteolytic activation - Genomic RNA replication3CLproIn silico predictionSARS‑CoV-Islam MT et al. (2020) Phytother Res - Zhang, D. H., (2020) J Integr Med
BetulonalTerpenes C. xylocarpaAutoproteolytic activation - Genomic RNA replication3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
GnidicinTerpenesG. lampranthaAutoproteolytic activation - Genomic RNA replication 3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
HesperidinGlycosides/HesperidinC. aurantium L. - Swertia genusAutoproteolytic activation - Genomic RNA replication 3CLpro - HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
PhyllaemblinolTerpenesP. emblicaAutoproteolytic activation - Genomic RNA replication 3CLpro - HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Sugetriol-3,9-diacetateTerpenesC. rotundusAutoproteolytic activation - Genomic RNA replication PLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Theaflavin 3,3′-di-O-gallateFlavonoidsC. sinensisAutoproteolytic activation - Genomic RNA replication 3CLpro - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Platycodin DGlycosides/SaponinsP. grandiflorasAutoproteolytic activation - Subgenomic RNAs transcriptionPLpro - Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
(R)-((1R,5aS,6R,9aS)-1,5a-Dimethyl-7-methylene-3-oxo-6-((E)-2-(2-oxo-2,5- dihydrofuran-3-yl)ethenyl)decahydro-1H-benzo[c]azepin-1-yl)methyl 2-amino-3-phenylpropanoateTerpenesA. paniculataGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
1,2,6-Trimethoxy-8-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-9H-xanthen-9-oneXanthenes/XanthonesS. mussotiiGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
1,7-Dihydroxy-3-methoxyxanthoneXanthenes/XanthonesS. pseudochinensisGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
1,8-Dihydroxy-6-methoxy-2-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-9H-xanthen-9-oneXanthenes/XanthonesS. kouitchensisGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
14-Deoxy-11,12-didehydroandrographolideTerpenesA. paniculataGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
14-hydroxycyperotundoneTerpenesC. rotundusGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
1-hydroxy-2,6-dimethoxy-8-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-9H-xanthen-9-oneXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
2β,30β-Dihydroxy-3,4-seco-friedelolactone-27-lactoneFriedelolactonesV. diffusaGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
3,5-dimethoxy-1-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-9H-xanthen-9-oneXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
3β,12-diacetoxyabieta-6,8,11,13-tetraeneTerpenes-Genomic RNA replication--SARS‑CoV-Islam MT et al. (2020) Phytother Res
8-(β-D-Glucopyranosyloxy)-1,3,5-trihydroxy-9H-xanthen-9-oneXanthenes/XanthonesS. mussotiiGenomic RNA replication RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
8,2-dihydroxy-3,4,5-trimethoxy-1-[(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)oxy]-9H-xanthen-9-oneXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
8β-hydroxyabieta-9(11),13-dien-12-one-C. harringtoniaGenomic RNA replication--SARS‑CoV-Islam MT et al. (2020) Phytother Res
AescinGlycosides/Saponins/EscinA. hippocastanumGenomic RNA replication--SARS-CoV (H.K. strain)Vero E6Wu CY., et al., (2004) Proc Natl Acad Sci U S A
Betulonic acidTerpenes-Genomic RNA replication- SARS-CoV- Islam MT et al. (2020) Phytother Res
FerruginolTerpenesS. sempervirensGenomic RNA replication--SARS‑CoV-Islam MT et al. (2020) Phytother Res
Ginsenoside-Rb1 Glycosides/SaponinsP. ginseng Genomic RNA replication--SARS-CoV (H.K. strain)Vero E6Wu CY., et al., (2004) Proc Natl Acad Sci U S A
HomoV.inPyrans/Benzopyrans/Chromans/FlavonoidsSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Kouitchenside AXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Kouitchenside HXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
MyricetinFlavonoidsA. perviridis - Myricaceae - Anacardiaceae - Polygonaceae - Pinaceae - PrimulaceaeGenomic RNA replication HelicaseIn silico predictionSARS‑CoV-Park, JY., et al., (2012) Biol Pharm Bull - Li, X.,et al., (2020) Preprints - Keum, Y. S., et al., (2012) Biochem Pharmacol
Phyllaemblicin BTerpenesP. emblicaGenomic RNA replication Helicase - RdRpIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Quercetagetin 6-O-β-D-glucopyranosideFlavonoidsSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
ReserpineAlkaloidsRauwolfiaGenomic RNA replication--SARS-CoV (H.K. strain)Vero E6Wu CY., et al., (2004) Proc Natl Acad Sci U S A
RutinPyrans/Benzopyrans/Chromans/FlavonoidsSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
ScutellareinPyrans/Benzopyrans/Chromans/FlavonoidsS. lateriflora - A. perviridisGenomic RNA replication Helicase-SARS-CoV-Keum, Y. S., et al., (2012) Biochem Pharmacol - Park, JY., et al., (2012) Biol Pharm Bull
SinefunginGlycosides/NucleosidesStreptomycesGenomic RNA replication RNA guanine-N7-methyltransferase-SARS-CoV-Sun, Y., et al. (2014) Antivir res
Triptexanthoside DXanthenes/XanthonesSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
α-glucosyl hesperidinFlavonoidsSwertia genusGenomic RNA replication HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
EmodinQuinonesRhubarbReceptor binding and viral entry S protein-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Excoecaria toxin TerpenesE. agallochaReceptor binding and viral entry S proteinIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
GlycyrrhizinTerpenesG. glabra rootReceptor binding and viral entry--Clinical isolates of coronavirus (FFM-1 and FFM-2)Vero E6Cinatl, J., et al., (2003) The Lancet - Chen, F., et al. (2004), J Clin Virol
LectinsLectinsPlantsReceptor binding and viral entryS protein-SARS-CoV (Frankfurt 1 strain)Vero E6Keyaerts, E., et al., (2007) Antivir res
LicoflavonolFlavonoidsG. uralensisReceptor binding and viral entry S proteinIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
MangostinXanthenes/XanthonesG. mangostanaReceptor binding and viral entry S proteinIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Phyllaemblicin G7TerpenesP. emblicaReceptor binding and viral entry S proteinIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Piceatannol StilbenesV. viniferaReceptor binding and viral entry S proteinIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
PsoralidinPyrans/Benzopyrans/CoumarinsP. corylifoliaReceptor binding and viral entry- SARS-CoV-Islam MT et al. (2020) Phytother Res
RheinQuinonesRhubarbReceptor binding and viral entry S protein-SARS‑CoV-Islam MT et al. (2020) Phytother Res
Saikosaponins B2Glycosides/SaponinsBupleurum sppReceptor binding and viral entry--HCoV-229E-Islam MT et al. (2020) Phytother Res
ChrysinPyrans/Benzopyrans/Chromans/FlavonoidsS. baicalensisReceptor binding and viral entry - Autoproteolytic activation S protein - PLproIn silico predictionSARS‑CoV-Islam MT et al. (2020) Phytother Res - Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
CosmosiinPyrans/Benzopyrans/Chromans/FlavonoidsS. baicalensisReceptor binding and viral entry - Autoproteolytic activationS protein - 3CLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
LuteolinPyrans/Benzopyrans/Chromans/FlavonoidsT. nuciferaReceptor binding and viral entry - Autoproteolytic activation3CLpro or Plpro-SARS‑CoV, HCoVs-Islam MT et al. (2020) Phytother Res
NeohesperidinPyrans/Benzopyrans/Chromans/FlavonoidsC. aurantiumReceptor binding and viral entry - Autoproteolytic activationS protein - 3CLpro - PLproIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Extract-Eucalyptus - G. scabra - D. batatas - C. tora - T. chinensis - C. barometz - H. cordata aq. - I. indigotica - L. japonica - P. ginseng - Rheum officinale Baill., P. multiflorum Thunb.Receptor binding and viral entry - Autoproteolytic activation - Genomic RNA replication S protein - 3CLproIn silico predictionSARS-CoV (H.K. strain)Vero E6Wu CY., et al., (2004) Proc Natl Acad Sci U S A - Islam MT et al. (2020) Phytother Res
HarmonylAlkaloidsFortunes bossfern rhizomeReceptor binding and viral entry - Autoproteolytic activation - Genomic RNA replication3CLproIn silico prediction--Zhang, D. H., (2020) J Integr Med
Hesperetin Glycosides/HesperidinI. indigoticaReceptor binding and viral entry - Genomic RNA replication--SARS‑CoV-Islam MT et al. (2020) Phytother Res
Kouitchenside DXanthenes/XanthonesSwertia genus - S. kouitchensisReceptor binding and viral entry - Genomic RNA replicationS protein - HelicaseIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
CefpiramideBeta-LactamsP. grandiflorasSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
JuglaninPyrans/Benzopyrans/Chromans/FlavonoidsP. aviculareSubgenomic RNAs transcription 3a protein-SARS‑CoV-Islam MT et al. (2020) Phytother Res
LymecyclineTetracyclinesP. grandiflorasSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
PiperacillinBeta-LactamsP. grandiflorasSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
StreptomycinGlycosidesP. grandiflorasSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
TetracyclineTetracyclinesP. grandiflorasSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
VitexinPyrans/Benzopyrans/Chromans/FlavonoidsV. negundoSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
Wogonoside FlavonoidsS. baicalensisSubgenomic RNAs transcription Nsp1, Nsp3c, and ORF7aIn silico prediction--Wu, C., et al. (2020). Acta Pharmaceutica Sinica B.
CepharanthineAlkaloidsS. tetrandraTranslation of S, M, and E proteinsS and N protein expression-HCoV-OC43MRC-5Kim, D. E., et al., (2019) Biomolecules
FangchinolineAlkaloidsS. tetrandraTranslation of S, M, and E proteinsS and N protein expression-HCoV-OC43MRC-5Kim, D. E., et al., (2019) Biomolecules
SilvestrolTerpenesAglaiaTranslation of S, M, and E proteins--HCoV-229E-Islam MT et al. (2020) Phytother Res
TetrandrineAlkaloidsS. tetrandraTranslation of S, M, and E proteinsS and N protein expression-HCoV-OC43MRC-5Kim, D. E., et al., (2019) Biomolecules